MultiSal™
Multi Component Delivery System
MultiSal™ is a free flowing powder of microspheres with high concentrations of encapsulated functional ingredients. This unique technology provides many benefits over free ingredients, such as: improved stability; shelf life; local targeting; and long-lasting release of actives. MultiSal™ is used to encapsulate drugs, essential oils, flavors, fragrances, skin treatments and anti-aging ingredients. Additionally, MultiSal™ enables one to control the release of multiple ingredients in a consecutive manner resulting in a longer lasting release and more potent product.Structure
MultiSal™ consists of solid hydrophobic nano or sub-micron spheres encapsulated in solid microspheres. MultiSal™ can be utilized to encapsulate multiple ingredients in the same carrier system and release them, one after the other, in a sequential manner, or alternatively, the same ingredient for a longer lasting release. MultiSal™ can also be utilized for site-specific targeted controlled release of active ingredients, such as pharmaceuticals, onto certain regions of the gastrointestinal tract (G-I) including the stomach and the small intestine.
Specific Features of MultiSal™
Benefits:
1. Enhanced stability of ingredients
2. Prolonged product shelf life
3. Delivery of multiple ingredients in a consecutive manner
4. Moisture triggered controlled release
5. pH triggered controlled release
6. Site specific delivery – Precise local targeting of ingredients to a specific site. (Ex: enhanced deposition of ingredients onto hair, hair follicles, and scalp to enhance ingredient efficacy)
7. Product benefits last longer due to extended release of ingredients
8. Enhanced bioavailability and efficacy of ingredients
9. Competitive edge, point of differentiation
Micro Sphere Technology
Characteristics
•Size: Micro spheres with a average diameter of 15-60 microns.
•Purpose: Seal volatile ingredients; transform liquid into solid, yielding a safe and more stabile product.
•Composition: Natural, natural modified, synthetic, and polymers blends.
Release: Triggered and modulated by water or pH change.
Picture 2: SEM Cross Section of Microspheres showing the wall of the microspheres. The space at the center is typically used to encapsulate NanoSal™.
Performance Features
The following are examples of commercial uses of MultiSal™ in final products:
1). MultiSal™ -Fresh Fragrance in a Deodorant Stick
The following are examples of commercial uses of MultiSal™ in final products:
1). MultiSal™ -Fresh Fragrance in a Deodorant Stick
The MultiSal™ functions as a fragrance delivery system to enhance the Fresh Fragrance. Note the release is modulated by body moisture.
Key for the Graph Above-
Light Blue: Control Fragrance
Violet: Salvona's Encapsulated Fragrance
2). MultiSal™ Flavor/Cooling, a product for anhydrous formulations.
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MultiSal™ can deliver multiple flavors and provide multi-sensorial effects by encapsulating multiple flavors or other sensory markers in NanoSal™ and than encapsulating them into MultiSal™. For example, MultiSal™ Flavor/Cooling in a lip balm makes the lips taste fruity upon application, which is followed by a sustained cooling sensation that can last for 30 min or up to an hour by simply wetting the lips.
This technology is also useful to provide combinations of very different flavors, such as sweet and sour.
The DSC shows Tm (melting point of NanoSal™ is at 60 degress Celsius). Although the NanoSal™ spheres are melting at 60 degrees Celsius, they do not release their encapsulated flavor. Only when the microspheres approach 160 degrees Celsius does the capsule break and release its contents.
The graph suggests that products formulated with flavors encapsulated in MultiSal™ are stable at a temp of 160 degrees Celsius, making them suitable for baking temperatures. Upon the breakdown of the microspheres at Tg, (Glass transition) the release of the flavor (as measure by wt loss) is accelerated upon the full depletion of the microspheres.
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