SalSphere® BPO

PID# 4900

A stable and targeted delivery system of benzoyl peroxide for the treatment of acne.

  • Stable form of benzoyl peroxide for the treatment of acne
  • Encapsulation allows for targeted delivery of BPO to the hair follicles and pimples, where acne-causing bacteria are active



Introduction

BPO is an FDA-approved acne treatment to clear pores and eradicate acne-causing bacteria. However, it is very difficult to formulate with due to these challenges. First, poor water solubility and high instability present a challenge. Second, it often results in skin dryness and discomfort. Third, its large particle size hinders its ability to penetrate the hair follicles and kill the acne-causing bacteria.

SS BPO is an encapsulation technology designed to enhance the acne treatment and tackle these BPO issues. SS BPO has superior stability and is more easily incorporated into finished products. Additionally, SS BPO has been designed to be compatible when combined with other encapsulated SalSphere® Rx actives for acne to maximize the efficiency without compromising stability.

Unique Features

  1. Ready for formulation - Improved stability and encapsulation provides a safe, quick, and easy way to formulate acne solutions.
  2. Targeted delivery - SalSphere® technology is designed to deliver BPO where it is needed most in the hair follicles to exert maximum effect.
  3. Gentle, slow release - With controlled release technology, SS BPO is gentle on the skin. The Repeat Insult Patch Test (RIPT) for SS BPO shows that it is a non-primary irritant, making it suitable for sensitive skin.

How the technology helps you

SS BPO is a sub-micron encapsulation system of benzoyol peroxide (Figure 1, 2). The small particle size of the technology is designed to facilitate the targeted delivery of benzoyl peroxide into the follicles. Upon application of the product, the sub-micron spheres adhere to the pimples, where they will dissolve and slowly release BPO directly into the hair follicles.

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Versions

VersionINCI & Characteristics
01

Water, Hydroxyethyl Behenamidopropyl Dimonium Chloride, Euphorbia Cerifera, Butyrospermum Parkii Butter, Benzoyl Peroxide

Technical Data

Appearance @ 20°C
Opaque liquid
Applications
Creams, lotions, spot treatments, and facial cleansers
Color
White to off-white
Odor
Characteristic
pH (1 % solution)
4.5 ± 1.5
BPO Assay (HPLC) (Wt.%)25 ± 10
Shelf Life (months)
36
Usage Level (wt%)
10-40
Storage (°C)
Closed container at 12-32°

Formula

Ingredients
(W/W %)
Water
86.3
SalSphere® BPO
10.0
Acrylamidopropyltrimonium
Chloride/Acrylates
Copolymer, Isohexadecane,
Coceth-7
3.0
Preservative
0.7