SalSphere® Hair Stimulator

PID# 8428

A targeted delivery of DHT blockers for hair growth

  • Stimulates, thickens and improves hair by enhancing access to nutrients.
  • Targets hair follicles to reduce the effect of DHT inhibitors.
  • Enhances the bioavailability of natural potent ingredients.



Introduction

SS HS is a sub-micron sphere that delivers DHT blocker (DHT=dihydrotestosterone) to hair follicles.

The common causes of hair loss are nutrient deficiency and the rogue hormone DHT. DHT plays a central role in hair miniaturization and loss. Although women don’t have nearly as much testosterone as men, when women undergo intense stress, the adrenal glands become overworked due to an increased need for the “stress hormone” known as cortisol. This causes the body to produce more adrenaline and testosterone, and DHT, a stronger variant of testosterone. When DHT binds to androgen receptors on hair follicles, the corresponding hair in the hair follicle becomes thinner and brittle.

The 5-alpha-reductase (5αR) enzyme restricting blood flow to a damaged hair follicle.

Unique Features

  1. Stable, Natural, Functional: Enables formulation of various hair care products with optimal dosage.
  2. Targeted Delivery: Targeted delivery to the hair follicles. Spheres are small to penetrate the hair follicles.
  3. Synergy: The complex offers a synergistic benefit.

DHT Blocker Complex

Caffeine: A team of German researchers found that caffeine blocks the damaging effects of DHT on hair follicles and stimulates the growth of new hair. "International Journal of Dermatology, 2007." Researchers based their findings on an in vitro study of caffeine's effect on hair follicle proliferation. It was found that only topical caffeine can be effective.

Azelaic Acid: A naturally occurring substance that studies have shown to inhibit 5-alpha-reductase in human skin.

Saw Palmetto: Blocks DHT

Zinc Sulfate: Zinc is a potent inhibitor of 5 alpha-reductase activity.

Designed for Targeted Delivery

The diameter of the hair follicular orifice is estimated to be at 30-50μm. SalSphere® delivery system with a diameter of 0.8μm can facilitate penetration into the hair follicle in a targeted manner, thus increasing its efficacy

Versions

Version
INCI & Characteristics
01Water, Beeswax, Polysorbate 80, Behenyl Alcohol, Butyrospermum Parkii (Shea) Butter, Caffeine Anhydrous USP/BP, Phenethyl Alcohol, Polyquaternium 67, Isopropyl Alcohol, Sodium Acetate, Sodium Chloride
28

Caffeine, Biotin, Azelaic Acid, Arginine, Carthamus Tinctorius (Safflower) Seed Oil, Zinc Sulfate, Saw Palmito, Lactic Acid, Glycine Soja (Soybean) Germ Extract, Triticum Vulgare (Wheat) Germ Extract, Serenoa Serrulata Fruit Extract, Scutellaria Baicalensis Root Extract, Gluconolactone, Butyrospermum Parkii (Shea), Water, Sodium Benzoate, Steareth-20, Cetyl Alcohol, Stearyl Alcohol, Glyceryl Stearate, Phenoxyethanol, Cetearyl Alcohol, Behentrimonium Methosulfate, Cetyl Alcohol, Behentrimonium Chloride, Propanediol, Butylene Glycol, Ethylhexylglycerin, Calcium Gluconate

35

China Compliant, Natural, PPG/PEG Free

Caffeine, Serenoa Serrulata Fruit Extract, Azelaic Acid, Zinc PCA, Arginine, Lactic Acid, Glycine Soja (Soybean) Germ Extract, Triticum Vulgare (Wheat) Germ Extract, Scutellaria, Baicalensis Root Extract, Biotin, Citric Acid, Glyceryl Stearate, Butyrospermum Parkii (Shea Butter), Cetearyl Alcohol, Glyceryl Stearate, Carthamus Tinctorius (Safflower) Seed Oil

Technical Data

Appearance @ 20°C
Opaque paste
ApplicationsLeave-on hair treatment applications such as serums, creams, and conditioners
Color White
White
Odor
Characteristic
pH (1% Solution)
4.0 ± 1.0
Shelf Life (months)
18
Usage Level (wt%)
3-5
Storage (°C) Closed container at 12-32°

DHT and it's Effect on Hair Loss

DHT attaches to the androgen and nutrients to hair follicles. However, receptors on the hair follicle. DHT increasing blood flow to the follicle will gradually miniaturizes the hair follicle also expose it to more DHT. In fact, causing the hair to die and fall out many men who apply minoxidil have their hair fall out in the first month.

The first approach to reduce DHT Studies found that the combination is commonly achieved by blocking of saw palmetto and beta-sitosterol 5-alpha-reductase which converts inhibit 5-alpha-reductase. They bind testosterone to DHT. to and block 5-alpha-reductase from Minoxidil works by increasing blood flow converting testosterone to DHT.

Testosterone is converted to dihydrotestosterone (DHT) by 5-alpha-reductase (5αR) enzyme.

The 5-Alpha-Reductase Enzyme

There are two types of 5-alphareductase (5αR) enzyme. Studies found that type II 5αR is primarily responsible for the male pattern baldness. It is localized in the vertex and frontal scalp where the hair loss is the most profound and usually not present in the lower back of the head where most bald men still have some hair. The optimum pH range of 5-alpha-reductase is pH 5-5.5. Outside of this pH range this particular enzyme can’t function.

Fortifying Shampoo Formula

Ingredients
(W/W %)
DI Water
61
SalSphere® Hair Stimulator
2
Sodium Lauryl Ether Sulfate
25
Cocamidopropyl Betaine
8
Glycerine
3
Phenoxyethanol, Ethylhexylglycerin
1