SalSphere® Natural Hair Growth Promoter

PID# 8337

Technology to reduce the signs of hair aging with a solution at the root of the problem.

  • Promotes fuller-looking hair.
  • Natural remedy for hair thinning and loss.
  • Targeted delivery of to hair follicles for faster and visible results.



Introduction

Hair loss, receding hairline, hair thinning and other common issues affect millions of people and may indicate aging. The OTC topical solutions on the market are alcohol-based which can cause irritation, itching and disappointment with the results.

SS NHGP is an all-natural solution that can be applied topically. The unique proprietary submicron spheres allow to deliver functional botanicals directly to the hair follicles.

Unique Features of SS NHGP

  1. Stabilized Apple Extract - SS NHGP contains purified and concentrated apple extract (procyanidin B2). The encapsulation stabilizes the extract, so that it can be used in practical topical formulations.
  2. Effective Targeted Delivery Technology - The SalSphere® technology delivers procyanidin B2 to hair follicles and as a result, the effects can be seen in a short time.
  3. Demonstrated Clinically - The efficacy of SS NHGP is supported by clinical studies. A study conducted with over 40 volunteers ages 25-60 have shown a significant increase in hair growth initiation after 21 days. The study revealed no adverse side effects. No patients complained of itchiness, pain, dryness or scaling of the scalp.

How the technology helps you

SalSphere® is available as a slurry. It is used as a raw material to formulate leave-in and rinse-off products. We recommend combining SS NHGP with SS Hair Stimulator for a synergistic effect. The combination of the technologies was found to be very useful because the cause behind thinning hair is not clear and a combination of technologies can be more effective to address the issue and get faster results. The two technologies deliver different functional ingredients and are compatible for formulation.

Powerful technology

The purpose of procyanidin encapsulation is to stabilize and reduce premature oxidation of the product. Apple exact and procyanidin are water-soluble. SalSphere® technology allows for transformation of the water-soluble potent ingredients into hydrophobic submicron spheres that are suspendable and can penetrate the hair follicles due to their size and hydrophobic nature. The submicron spheres encapsulate the procyanidin B2 and release their content over time at the hair roots for effective and targeted delivery.

SS NHGP is a technology grounded in many years of research on multiple levels

The efficacy of SS NHGP as applied topically is supported by clinical studies. It’s a 100% drug-free, natural ingredient, without the known unwanted side effects, encapsulated in the groundbreaking proprietary technology.

The functional ingredient is procyanidin B2 oligomer, a natural source of polyphenols that belong to the class of bioflavonoids, catechin. This compound is found in the skins of unripe green apples. Clinical studies at the Tsukuba Research Laboratories in Japan have shown that topical application of procyanidin B2 improves hair growth and hair diameter.

Source of procyanidin B2

In clinical studies, 71% of subjects showed an increased number of hairs, and 78.9% showed an increased mean value of hair diameter. The results identified procyanidin B2 from apples to be a powerful stimulant that promotes hair epithelial cell growth more than 300% relative to controls at a concentration of 30 μM.

Although this form of application was found successful, the therapy requires 6 months of daily application to see results, which is considered as a long time for most consumers. In addition, the attempt to utilize pure procyanidin in commercial application did not show expected results due to three major reasons: 1. The high solubility of procyanidin B2 in water at pH 7.2 is approximately 10 mg/ml which makes it easy to get rinsed off. 2. Procyanidin is not adhering nor penetrating into the follicles efficiently, and 3. Procyanidin tends to get oxidized in a short time changing the color to dark brown. Encapsulation of procyanidin into submicron sphere found to be the ultimate solution to enable successful commercial use.

Functional Ingredient

CAS: 29105-49-8

Synonyms: Epicatechin, Proanthocyandidn B2

Molecular structure: Procyanidin B2 is a proanthocyanidin consisting of two molecules of (-)-epicatechin joined by a bond between positions 4 and 8’ in a betaconfiguration.

Procyanidin B2 enhances the proliferative capacity of hair epithelial cells to minoxidil and control.

Efficacy of Procyanidin B2 versus minoxidil1

Enhanced shelf life

SalSphere® technology effectively shields procyanidin B2 from oxidative forces and maintains the aesthetics and potency in final product formulations. Free procyanidin B2 turns dark brown in a formula whereas a product using SalSphere® remains lighter in color.

Pictures of a lotion containing SalSphere® NHGP (A) and a lotion containing free apple extract (B) after stability testing under accelerated conditions of 42°C. Within 3 months, the free apple extract gets discolored turning dark brown.

Targeted delivery

The diameter of a hair follicle orifice is estimated to be in the range of 30-50 μm. The SalSphere® delivery system, with a diameter of 0.1-0.3 μm, can facilitate penetration of procyanidin B2 into the hair follicle in a targeted manner increasing the efficacy.

Illustration of mode of penetration of SalSphere® NHGP into the hair follicle.

Mechanism of Action

Utilizing fluorescent agents encapsulated in SalSphere® demonstrated the targeted delivery of the submicron spheres containing the active to the hair follicles. The targeted delivery of procyanidin B2 can specifically promote hair epithelial cell growth, activate specific regions of the hair follicle into the growing phase, and cause the follicular hair cycle to revert to the anagen phase from the telogen phase. Thus, it is suggested to be effective in curing male pattern baldness.

Studies have shown that procyanidin B2 prolongs the hair growth cycle and shortens the rest cycle.

Versions

Version
INCI & Characteristics
11

Pyrus Malus (Apple) Fruit Extract, Butyrospermum Parkii (Shea) Butter, Water, Beeswax, Hydroxyethyl Behenamidopropyl Dimonium Chloride, Behenyl Alcohol, Phenoxyethanol, Ethylhexylglycerin

23

Apple Fruit Extract (Pyrus Malus), Glyceryl Stearate, Stearyl Alcohol, Butyrospermum Parkii (Shea) Butter, Cocamidopropyl PG-dimonium Chloride Phosphate

34 Isostearyl Isostearate, Glyceryl Stearate, Cetearyl Alcohol and Cetearyl Glucoside, Butyrospermum Parkii (Shea) Butter, Propanediol, Xanthan Gum, Aqua, Rice Extract, Sodium Citrate Dihydrate, Lactic Acid , Phenethyl Alcohol (and) Pentylene Glycol (and) Propanediol, DL-alpha-Tocopherol, Tetrahexyldecyl Ascorbate, Pyrus Malus (Apple) Fruit Extract

Technical Data

Appearance @ 20°C
Opaque Cream
Applications
Suitable for hair care applications such as conditioners, shampoos, serums, and styling products
Color
From white too off white
Odor
Characteristic
pH (1 % solution)
4.5 ± 1.5
Shelf Life (months)
18
Usage Level (wt%)
3-5
Storage (°C)
Closed container at 12-32°

SS NHGP water-based slurry

 

All formulas are China Compliant & PEG Free

Foaming Mousse Formula

Ingredients
(W/W %)
SS NHGP PID# 8337
5.00
SS SalOxy PID# 5079-03
7.50
Propanediol
5.00
Carrageenan
0.75
Xanthan Gum
0.35
Phosphate Buffered Saline (and) Aqua
1.00
Sodium Laureth Sulfate
2.25
Cocamidopropyl Betaine
2.25
Oryza Sativa (Rice) Extract
1.50
Citrus Grandis(Grapefruit) Peel Oil
0.05
Phenethyl Alcohol (and) Pentylene Glycol (and) Propanediol
0.75
Blue 1
0.01
Water (Aqua)
73.59

Fixative Formula

Ingredients
(W/W %)
SS NHGP PID# 8337
3.00
HS SalSilk PID# 8392-13
3.00
Water, Carbopol, Phenoxyethanol, Ethylhexylglycerin, Disodium EDTA
25.00
Phenethyl Alcohol (and) Pentylene Glycol (and) Propanediol
1.00
Propanediol
1.00
Water, Arginine
1.00
PVP
1.50
Water (Aqua)
63.50

Serum Formula

Ingredients
(W/W %)
SS NHGP PID# 8337
2.00
SS Hair Stimulator PID# 8428-34
3.00
Polyhydroxystearic Acid
1.00
Sodium HydroxyPropylSulfonate LaurylGlucoside CrossPolymer
1.78
Phosphate Buffered Saline
0.01
Disodium EDTA
0.10
Phenethyl Alcohol (and) Pentylene Glycol (and) Propanediol
1.00
Lactic Acid
0.01
Aqua (and) Acrylates/C10-30 Alkyl Acrylate Crosspolymer
18.00
Arginine
0.10
Propanediol
4.00
Glycerin
46.00
Water (Aqua)
23.00